S.I. 5 exciting developments in the management of Wilson’s disease, 3 exciting emerging interventional treatments for Parkinson’s disease, The 12 most viewed blog posts on The Neurology Lounge in 2019, 7 remarkable technologies shaping the future of the brain. Graus F et coll. The 7 most hazardous occupations to the nervous system, A few more helpful and practical neurology checklists, Monumental breakthroughs in the history of neuroscience, On the seizure-detecting instincts of pets, 25 non-eponymous neurological disorders… and the names behind them, 10 more catchy titles from the recent neurology literature, 7 remarkable patients who determined the course of neuroscience, The case for testing serum neurofilament light protein in MS, The cutting-edge applications of ultrasound in neurology. The memory of patient 1 recovered fully and he died from an unrelated cause 1 year later; neuropsychological testing showed a severe, but isolated, anterograde amnesia, brain MRI was normal and HMPAO-SPECT showed left medial temporal hypoperfusion. It is characterized by low self esteem, anxiety, inability to take decisions and increased risk for depression — … The patient improved with aggressive immunotherapy. Twenty-two (41%) of the 53 patients revealed valvular abnormalities, with mitral regurgitation in 28%, aortic regurgitation in 9%, and both in 4%. Indirect neurologic dysfunction may be caused by paraneoplastic disorders (such as paraneoplastic cerebellar degeneration or limbic encephalitis) and primary angiitis of the central nervous system. Pour Ophélia Godin, épidémiologiste au sein de la Fondation FondaMental, ces résultats sont intéressants et dénotent d’une différence marquée entre les pathologies. Immune therapy in autoimmune encephalitis: A systematic review, Unusual Presentation of Hodgkin Lymphoma with Limbic Encephalitis (Ophelia Syndrome), Autoimmune Movement Disorders in Children, Psychohematology. What are the 695 topics that make up neurology? Patient 2 remained densely amnesic despite regression of her lung tumour; neuropsychological testing disclosed both anterograde and extensive retrograde amnesia together with more generalised cognitive deficits including anomia and executive impairments, MRI showed gross atrophy of the hippocampus and amygdala bilaterally, and HMPAO-SPECT showed pronounced frontal and temporal hypoperfusion. To report two cases of paraneoplastic limbic encephalitis (PNLE) with similar clinical presentation, but dramatically different outcome and to highlight the role of neuropsychological and radiological evaluation in PNLE. Chemotherapy alone may improve survival because it is associated with fewer late deaths. Two women aged 33 and 61 presented with uncontrolled complex partial seizures, profound memory loss and cognitive decline. Ophelia Syndrome is best described as thinking or feeling a certain way because a person is told to. Tantabus Syndrome is a type of sickness that can be experienced by devote disciples of Princess Luna, i.e Ophelia Sparkle and Prince Somber Moon. Magnetic resonance imaging (MRI) was normal in both patients. Neurologic and/or neuropsychiatric symptoms combined with typical MRI findings should raise the suspicion of PS and lead to further diagnostics for an underlying tumour even in children. Among those assigned to subtotal nodal radiation therapy, patients who had a favorable risk profile received subtotal nodal radiation therapy alone and patients with an unfavorable risk profile received two cycles of ABVD plus subtotal nodal radiation therapy. Febrile neutropenia developed nine times in eight patients, and eight episodes of febrile neutropenia developed when the treatment-day absolute neutrophil count (ANC) > or =1000. Cardiac late effects are responsible for a significant burden of mortality and morbidity among pediatric Hodgkin's lymphoma (HL) survivors (HLS). Neuropathological examination revealed that the pathology was confined to the hippocampus, both hippocampi showing sclerosis without inflammation. 16,[18][19][20][21][22][23][24][25]. There was no evidence of global hypoxia, or of neurodegenerative disorders with pathological changes affecting the hippocampus. Deanna will be performing live from the basement Saturday in Ophelia Syndrome’s jam space. We report an unusual case of paraneoplastic limbic encephalitis (PLE) in a 17-year-old adolescent with classical Hodgkin lymphoma. 18 The cases reported in the English literature are summarized in Table 3. Twenty-five of 44 (57%) patients with MRI studies had signal abnormalities in the limbic system. DIAGNOSING AND TREATING THE OPHELIA SYNDROME By Thomas G. Plummer; BYU Magazine; In Hamlet, Act 1, Scene 3, Laertes warns his sister, Ophelia, to avoid falling in love with Hamlet, whose advances, he claims, are prompted by fleeting, youthful lust. Immunoprecipitation, mass spectrometry, and mGluR5 -null mice served to … Neutropenia and febrile neutropenia in patients with Hodgkin's lymphoma treated with doxorubicin (Ad... Nodular sclerosis Hodgkin lymphoma with classic Reed-Sternberg cells, Clinical and Subclinical Cardiac Late Effects in Pediatric Hodgkin's Lymphoma Survivors, ABVD Alone versus Radiation-Based Therapy in Limited Stage Hodgkin’ s Lymphoma. In nosologic aspect, mental disorders in HL are classified as somatogenic and adjustement disorders. Another thought of herself as a dog jumping through a hoop. Yes, you read it correctly. Conversion disorders and behavioral disorders that lead to non-compliance in patients with HL are described as well. Ophelia syndrome is named after Shakespeare’s unfortunate Danish maiden, and it was first described by Dr. Ian Carr whose daughter, at the age of 15, developed progressive loss of memory, depression, hallucinations, and bizarre behaviour. The Othello syndrome affects males and, less often, females. The commonly associated neoplasms were of the lung (50%), testis (20%) and breast (8%). Lancet. Are parasites the simple solution to the problem of MS? Encephalitis was reversible in both patients receiving tumor treatment. There are different psychogenic states among the adjustment disorders. For example, some young girls feel the pressure to be thin or to change their bodies because the media communicates in different ways what, by the mainstream media's … Ophelia Syndrome is when a person is "chronically ignorant, chronically dependent, and chronically submissive." Results: There was obtained information on the prevalence, typologies, risk factors and treatment of blood diseases in the available literature. This literature review differentially describes mental disorders in patients with Hodgkin’s lymphoma (HL) with an emphasis on psychotic disorders, affective states and adjustment disorders. The DSM-IV Diagnostic Criteria for PTSD provides a checklist of symptoms that may be used to detect the disorder in Ophelia. In most cases of adjustment disorders there was observed a combination of several risk factors (both general and specific). Mollaret meningitis is a type of meningitis due to a viral infection (aseptic meningitis) that occurs multiple times. Which drug reduces the autoimmune risks of alemtuzumab? The main antibody in this group targets the metabotropic glutamate receptor 5 (mGluR5). The second patient presented with psychosis and panic disorders, but the condition was later found to be caused by paraneoplastic limbic encephalitis due to ovarian teratomas. Background: Fifteen of 34 (44%) patients with a median follow-up of 8 months showed neurological improvement. Paraneoplastic syndromes in Hodgkin lymphoma (HL) can be seen with different symptoms and organ findings within a significant time before definite diagnosis of the primary disease. Ophelia Syndrome is best described as thinking or feeling a certain way because a person is told to. Their subsequently diagnosed small cell lung cancer was treated with a combination of radiotherapy and chemotherapy, leading to remission of the tumour. Abstract Objective: To report the metabotropic glutamate receptor 5 (mGluR5) as the autoantigen of antibodies from 2 patients with Hodgkin lymphoma (HL) and limbic encephalopathy (Ophelia syndrome). Ophelia is worse than naive. 16,18-29 The association of LE with HL is also known as Ophelia syndrome. Patients with anti-Hu antibodies usually had small-cell lung cancer (94%), multifocal neurological symptoms (78%) and a poor neurological outcome. First, a person must have been “confronted with an event or events that involved actual or threatened death or serious injury, or a threat to … Methods: Immunohistochemistry with brain tissue and cultures of rat hippocampal neurons were used to demonstrate antibodies. Second, onconeural antibodies are absent in most PNS associated with lymphomas with the exceptions of Tr (DNER) in PCD and mGluR5 in limbic encephalitis (LE). Down Syndrome Analysis. These cases illustrate that patients with paraneoplastic neurological syndromes may present with psychiatric symptoms which can hamper an early diagnosis. Yes, you read it correctly. 1. They are not able to think independently and just allow all of their thoughts and actions be dictated by what others tell them to think and do. We randomly assigned 405 patients with previously untreated stage IA or IIA nonbulky Hodgkin's lymphoma to treatment with, Access scientific knowledge from anywhere. Purpose: This article describes studies involving mental and personality disorders in patients with blood diseases - disorders typology, prevalence, risk factors for developing of mental disturbances and their treatment. One reading of Ophelia's suicide later in Hamlet suggests that because she has no thoughts of her own, because she listened only to the contradictory voices of the men around her-- Laertes, Polonius, and Hamlet-- she reaches a breaking point. ... [106] He called this Ophelia syndrome and described resolution of the neurological symptoms with tumor treatment. With grade III/IV neutropenia on the day of therapy, 158 treatments were administered without dose reduction or dose delay with one subsequent episode of febrile neutropenia. Nos résultats dans les troubles bipolaires et la schizophrénie montraient une prévalence du syndrome métabolique chez les patients respectivement de 20% et de 24%. diseases and to develop differentiated approaches to pharmacotherapy and psychotherapy in such states. In the context of the tolerability and safety of pharmacotherapy preference was given to atypical antipsychotics and new generations of antidepressants (SSRI, SNRI). PWYC. On thorough cardiac assessment a mean of 21 years after their diagnosis, none of the 53 unselected asymptomatic HLS showed physical signs or significant ECG abnormalities during or after the stress echo test. Similarly, Carr's daughter had a full recovery in the absence of immune therapy. Methods: Immunohistochemistry with brain tissue and cultures of rat hippocampal neurons were used to demonstrate antibodies. Objective: To review the origins of the Ophelia’s syndrome through the original description and its relation to Shakespeare’s character, and the related autoantibodies. HL is the third most common cause of LE after SCLC and testicular germ cell tumors. 1982 ; 1 : 844-5. and What’s evolving at the cutting-edge of autoimmune neurology? This illness can take hold of those walking through the dreams of others and if not treated can lead to effects that can be experienced within the waking world. Patients in the ABVD-only group, both those with a favorable risk profile and those with an unfavorable risk profile, received four to six cycles of ABVD. Recognition of this disorder is important because it can affect young individuals and is reversible. "Ophelia Syndrome Commentary" Essays and Research Papers . The clinical picture with this antibody is a form of encephalitis which may manifest with prosopagnosia (difficulty recognising faces), and with the curious Ophelia syndrome. Deanna will be answering your questions, premiering some new material, and giving a little behind the scenes intel. Antibody against mGLUR5 seems to be associated for this presentation. Neurology can’t seem to get away from autoimmune disorders of the central nervous system. New Research Shows How Our Brain Responds to Both. View Ophelia Syndrome.pdf from STDEV 117 at Brigham Young University. A PET scan six months later was normal. and dose modification, in a large university patient population. All Ages. She is an adult who chooses to be a baby, one who does not know her own opinions and who would not express them to an authority if she did. 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